By: S. Munir Alam, PhD
https://medicine.duke.edu/faculty/s-munir-alam-phd
It acknowledges an epitope within the N-terminus these missing estrogen and/or progesterone receptor order cheap lozol blood pressure medication how long to take effect, or with of p53 protein 1.5mg lozol for sale arteriogram cpt code. About 50% of breast carcinomas are Specificity: Recognizes a 53kDa protein order lozol 2.5 mg without prescription blood pressure line chart, which is identified as positive for p53 especially these missing estrogen and/or p53 suppressor gene product buy 2.5 mg lozol otc arrhythmia recognition. Its epitope maps throughout the N 22-76% of colon, stomach, bladder, breast, lung and testes terminus (aa 37-forty five) of p53. A00021-0002 2 ml Catalog Number Volume A00021-0007 7 ml A20093 2 ml A00021-0025 25 ml A00093 6 ml A00093. Will not cross-react with mouse or Positive Control: Tonsil or reactive lymph node. A00109-0002 2 ml Catalog Number Volume A00109-0007 7 ml A20022 2 ml A00109-0025 25 ml A00022 6 ml A00022. Isotype: IgG2b, kappa Positive Control: About 50% of breast carcinomas are positive Species Reac vity: Human. A00154-0002 2 ml Catalog Number Volume A00154-0007 7 ml A20027-0002 2 ml A00154-0025 25 ml A00027-0007 7 ml A00027-0025 25 ml ScyTek Laboratories, Inc. Specificity: Recognizes proteins of 21-24kDa, identified as the A Specificity: Recognizes a protein of 52kDa, identified as prostate and B subunits of S100 protein. Antibody to S100 stains reacts with non-neoplastic grownup and fetal prostatic glands, Schwannomas, ependymomas, astrogliomas, nearly all benign major and metastatic prostatic carcinomas. S100 protein is is really helpful for immunohistochemical staining of formalin also expressed within the antigen presenting cells such as the fixed, paraffin-embedded tissues. S100 protein is very soluble and osteoclasts, parietal cells of the stomach, liver cells, renal cell or may be eluted from frozen tissue during staining. Catalog Number Volume Catalog Number Volume A00087-0002 2 ml A20041 2 ml A00087-0007 7 ml A00041 6 ml A00087-0025 25 ml A00041. Specificity: this antibody reacts with each free and sure Positive Control: Kidney. A00118-0007 7 ml Positive Control: HepG2 cells, Melanoma, breast carcinomas, A00118-0025 25 ml gliomas. Catalog Number Volume A00161-0002 2 ml A00161-0007 7 ml A00161-0025 25 ml ScyTek Laboratories, Inc. Cellular Localization: Cytoplasmic Positive Control: Human Melanoma Specificity: Thyroglobulin is a 660 kDa dimeric preprotein with Specificity: Tyrosinase has been shown to be a really specific multiple glycosylation sites is produced by and processed inside marker for melanomas. Cross reactivity with different tumors or the thyroid gland to provide the hormone thyroxine and regular tissues examined has not been reported. Prior to forming dimmers, thyroglobulin Catalog Number Volume monomers bear conformation maturation within the endoplasmic reticulation. Thyroglobulin dimerization in addition to A00132-0002 2 ml transport of thyroglobulin to the Golgi complex is calcium A00132-0007 7 ml dependent. Thyroglobulin defects resulting from faulty dimer A00132-0025 25 ml formation and export to the Golgi is believed to cause some types of goiter. Hence the presence of Clone: 31A3 thyroglobulin autoantibodies may help to determine disease. Isotype: Mouse IgG1, Kappa An physique to thyroglobulin has been shown to be useful for the Species Reactivity: Cow, Human, Mouse, Pig, Rat. It is essential to in addition to small nerve fibers in peripheral tissues, together with notice though that not every sort of thyroidal lesion is epidermal tissues (Day & Thompson, 2010). The antibody also thyroglobulin antibody positive, a variety of types are unfavorable. This antibody has also identified UchL1 Catalog Number Volume expression in renal tubule spermatogonia, testis, ovary, and each pregnant and non-pregnant corpus luteum. In the thyroid, follicular and mesenchymal cells and is subsequently of value within the differential parafollicular cells are positive. Adenocarcinomas are usually positive, whereas Squamous Cell Species Reactivity: Human. In Catalog Number Volume addition, Small-Cell Carcinomas (of any major site) are usually positive. Tonsil or Specificity: Recognizes a fifty seven-60kDa protein which is identified as follicular lymphomas. In regular tissues, sialyl Lewisa antigen is Species Reactivity: Human, Baboon, Cow, Rabbit, Mouse, Rat, current in ductal epithelium of the breast, kidney, salivary gland, Chicken. It reveals no cross response with actin from fibroblasts (b sufferers with stage I pancreatic carcinoma decrease to regular and g-cytoplasmic), striated muscle (a-sarcometric), and values following surgery. Its epitope is composed of the acetyl recurrence of disease prior to radiographic or clinical findings. Catalog Number Volume Specificity: Human Bcl-2 alpha is a 239 amino acid (aa) protein and human Bcl-2 beta is a 205 aa protein. The 100/D5 antibody A00135-C 1 ml [also referred to as clone Bcl-2/100 (Kren, 2004, Kaur, 2004)] acknowledges each Bcl-2 isoforms (Pezzela et al, 1990). Specificity: Recognizes a 100kDa glycoprotein, identified as Posi ve Control: Tonsil, Angiosarcoma. Isotype: IgG1, Kappa Positive Control: Daudi, Raji, and U266, and human Species Reactivity: Human. Positive Control: Tonsil Specificity: Recognizes a protein of 30-33kDa, which is identified Cellular Localization: Primarily membrane. This antibody reacts with endothelial cells in regular tissues and in benign and Catalog Number Volume malignant proliferations. This Mab distinguishes giant cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. Isotype: IgG1, kappa Specificity: this antibody is particular for hematopoietic cells, Species Reac vity: Human, Cynomolgus Monkey, Rhesus together with basophils, granulocytes, lymphocytes, macrophages / Monkey. Isotype: Mouse IgG1 Specificity: this antibody acknowledges a cell floor glycoprotein Species Reactivity: Human. Specificity: this antibody is particular for hematopoietic cells, together with basophils, granulocytes, lymphocytes, Catalog Number Volume macrophages/histiocytes, mast cells, monocytes, plasma cells; A00082-C. This antibody reveals no reactivity with regular B or natural killer cells, but reacts with granulocytes and monocytes. Though this antibody is beneficial to determine T-cell lymphomas and leukemia, uncommon staining with B cell lymphomas reported. Isotype: IgG2a, Kappa Positive Control: Tonsil, Neuroblastoma, Pancreatic Islet cells. Specificity: this antibody acknowledges two proteins (185kDa & Positive Control: Mantle cell lymphoma and breast carcinoma. Results with this antibody have helped to indicate tissues, and neoplasms corresponding to retinoblastoma, that Cyclin D1 is over expressed in many alternative kinds of medulloblastoma, astrocytoma, and neuroblastoma. For example, about 50-70% of mantle cell lymphomas expressed on some mesodermally derived tumors corresponding to and forty% of breast carcinomas are cyclin D1. Reacts weakly with mouse, rat and Isotype: IgG1, Kappa (Both) guinea pig Cytokeratin 19. Others Positive Control: Skin, Breast carcinoma, Colon carcinoma, not recognized Thyroid. Adrenal gland, bowel, thyroid, Specificity: this antibody reacts with the rod domain of human pancreas, or pheochromocytoma. The antibody recognition Specificity: Chromogranin A is current in neuroendocrine cells epitope maps between amino acid 312-335. Specificity: Cytokeratin 6 is expressed in many non-keratinizing Positive Control: Human epidermal keratin or carcinoma. Twenty root sheath of hair follicles, esophagus, oral mucosa, in addition to human keratins are resolved with two-dimensional gel basal cells in prostate glands and myoepithelial cells in mammary electrophoresis into acidic (pI<5. Immunogen: Human epidermal keratin Positive Control: Carinoma of Ovary, Lung, Cervix or Breast. This antibody stains cytokeratins current in regular and abnormal human tissues and has shown excessive sensitivity within the recognition of epithelial cells and carcinomas. Specificity: Desmin, Clone D33 detects cells of regular easy, A00128-C 1 ml skeletal, and cardiac muscle tissue. It reveals no Species:Mouse cross-response with different intermediate filament proteins. Immunogen: Delipidated extract of human milk fats globule Catalog Number Volume membranes A00158-C. In immunohistochemical assays, it Specificity: Detects insulin and insulin producing cells. Clone: 11D5 Specificity: this monoclonal antibody is particular to the kappa Isotype: IgG1, Kappa gentle chain of immunoglobulins and reveals no cross-response with Species Reactivity: Human the lambda gentle chain or any of the five heavy chains. The nuclei of the estrogen receptor positive cells stain very strongly with this antibody, without any staining Species: Mouse within the cytoplasm. However, on cryostat sections a positive Clone: L1C1 staining of estrogen receptor within the nucleus in addition to cytoplasm Isotype: Mouse IgG1, Kappa may be seen. Specificity: the kappa gentle chain antibody acknowledges the kappa gentle chain of immunoglobulin. Isotype: IgG1, kappa Specificity: this monoclonal antibody is particular to the lambda Species Reactivity: Human. Species: Mouse Catalog Number Volume Clone: M2-7C10 Isotype: Mouse IgG2b, Kappa A00153-C. Positive Control: Human Melanoma A00116-C 1 ml Specificity: Melanoma; Pan is a broad spectrum marker for metastatic melanoma. Species: Mouse Catalog Number Volume Clone: 45M1 A00133-C 1 ml Isotype: Mouse IgG1, Kappa Species Reactivity: Human, Monkey, Cat, Chicken, Hedgehog, Mouse, Pig, Rabbit, Rat. Specificity: this p53 antibody acknowledges a 53kDa protein, which Positive Control: Lung adenocarcinoma. The antibody Specificity: this antibody is particular for a pepsin-like aspartic reacts with the mutant in addition to the wild form of p53 underneath proteinase identified as Napsin A. Specificity: this antibody stains neurons (axons) of the central Posi ve Control: HepG2 cells. Although the precise epitope tissues together with breast tubules and ducts, the floor of for the antibody has not been mapped, the epitope appears to epididymal tubular epithelia, and the colloid of thyroid follicles. However due to the reported excessive expression of gp200 in Catalog Number Volume renal cell carcinoma, gp200 is most commonly known as Renal Cell Carcinoma Marker. Specificity: Thyroglobulin is a 660 kDa dimeric preprotein with multiple glycosylation sites is produced by and processed inside Specificity: Recognizes proteins of 21-24kDa, identified as the A the thyroid gland to provide the hormone thyroxine and and B subunits of S100 protein. Prior to forming dimmers, thyroglobulin calcium binding proteins corresponding to calmodulin and troponin C. Antibody to S100 stains transport of thyroglobulin to the Golgi complex is calcium Schwannomas, ependymomas, astrogliomas, nearly all benign dependent. Thyroglobulin defects resulting from faulty dimer and malignant melanomas and their metastases. S100 protein is formation and export to the Golgi is believed to cause some types also expressed within the antigen presenting cells such as the of goiter.
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Invasive breast cancer has not elevated significantly since 1987 and has truly declined since 2000 buy cheap lozol 1.5mg line arrhythmia course certification. The data revealed higher increases over time in incidence per 100 discount lozol 1.5mg on-line heart arrhythmia 4 year old,000 inhabitants than per 1 generic lozol 2.5 mg blood pressure chart pdf,000 screened (Figure 32) lozol 2.5mg without prescription arteria 2000. The National Surgical Adjuvant Breast and Bowel Project P-1 research examined the protecting impact of tamoxifen among excessive danger women. The International Breast Cancer Intervention Study enrolled 7,152 excessive danger women between the ages of 35 and 70 from the United Kingdom, Australia, and New Zealand. The Royal Marsden breast cancer prevention 107 trial assigned 2,494 wholesome women to oral tamoxifen (20mg/day) or placebo for eight years. However, the research also discovered with each remedies the risk of invasive breast cancer decreased by half. As a outcome, there are ongoing efforts to improve the sensitivity and specificity of screening modalities, notably for ladies at excessive danger of developing breast cancer. However, the one hundred fifty five proportion of false-optimistic outcomes with ultrasound was greater than with mammography. Evidence from screening research in women with radiographically dense breasts advised that 156 157,158 zero. Two research reported that the specificity of ultrasound is lower in younger 154,one hundred fifty five women than older women. In addition to screening mammography, ultrasound can accurately distinguish some strong lesions as benign, reducing the charges of unnecessary 159,a hundred and sixty biopsy. The American Cancer Society Guidelines for Breast Cancer Screening discovered restricted scientific evidence for effectiveness or equivalence of ultrasound to screen-film one hundred fifty five mammography for screening for breast cancer. Finally, the European Group for Breast Cancer Screening consensus assertion stated the value of diagnostic ultrasound for targeted examination of each palpable and impalpable breast 31 168 abnormalities with no evidence to support screening ultrasound in asymptomatic women. Understanding this impact and how finest to forestall all types of breast cancer deserves additional attention. Surgical decisionmaking typically takes the following components under consideration: 181-196165,166,197 multicentric disease, tumor size, and contralateral disease. We excluded research when a later publication from the same institution included sufferers from an 181,236 237-240 earlier research. Despite these similarities, variability within the definition of multicentric disease limits comparisons across research. For instance, Hollingsworth defined multicentric disease as a separate focus of cancer more than 231 5. Thus, pathological examination can overestimate or underestimate tumor sizes, depending on the aircraft of part. The majority of the research included middle aged women (median age 50-60 years); few 237,255,270 259 particularly centered on younger (median age <50) or older (median age >60) sufferers. Common choice criteria listed by many authors include palpable mass, radiographic mass, massive size, mastectomy treatment, excessive 248,264,274 nuclear grade, and suspicion for invasive breast cancer. For our final evaluation, we excluded several research for the following causes: sixty eight 1) A later publication from the same institution included sufferers from an earlier 236 237-240 research. No research reported chemotherapy use; sixteen reported regional recurrence and forty four report distant recurrence. Even clinically, this is hardly ever absolutely explored and never clearly useful with decisionmaking. Ernster also stories that breast cancer mortality declined significantly between 1978-1983 and 1984-1989 (10 year mortality at 10 years three. Estimates of 5 or 10-year recurrence charges are remarkably unstable across research starting from 2. This raises questions on whether or not danger of recurrence is secure over time, whether or not it increases or decreases. When mixed with invasive contralateral breast cancer, 299-303 incidence rises to as much as eight % after 10 years. While considerably beyond the scope of this report, several small research provide some evidence of survival after native recurrence. Solin stories on the experience of forty two circumstances with native 305 recurrence and estimated an actuarial 5-year breast cancer mortality fee of about sixteen %. Thus, whereas survivable, native recurrence is critical and stopping native recurrence is clearly preferable. There was, nonetheless, appreciable variability across research by way of how margins have been defined or categorised. For 325,326 instance, some research categorised margins as ?free or ?concerned whereas others use extra 327,328 329 precise measures corresponding to <1mm. We synthesized the evidence individually from observational research of better quality that reported multivariate adjusted estimates of the association between patient outcomes and margin 297,298,308-310,312,313,315,316,318-321,330 status (14 research) (Table 11). The majority of such research reported a optimistic important association between optimistic margins and recurrence. Other research reported a nonsignificant improve within the odds of native recurrence in women with concerned 316 margins after lumpectomy with or with out adjuvant radio or chemotherapy and elevated danger of native recurrence in women with close or concerned margins after lumpectomy or 315 mastectomy. Margins of 10mm or extra have been associated with the largest discount (ninety eight %) within the danger of native recurrence, whereas no variations have been seen utilizing a cut off of 2 or 4mm. Estimates typically categorised tumors much less 320 than 20mm as ?small though some defined small as <5mm. The association between tumor grade and patient outcomes was reported in 39 295,296,306,307,309-313,315-317,320,321,323,325,327,329,330,335,339-343,345,347-349,351,353-361 research (Table 13). Two research, each with less than 300 women, examined the association between tumor grade and mortality. The association was of comparable magnitude however not statistically important for ladies handled with lumpectomy alone. No research 345,347,356 discovered an elevated danger of contralateral cancer associated with tumor grade. While several research failed to seek out statistically important associations between intermediate and low 296,310,312,347 322 grade tumors, Kerlikowske discovered important elevated danger of recurrence for grade 2 versus grade 1 tumors in a cohort of 1,036 women handled with lumpectomy alone. Overall, the research recommend that the distinction between grades 2 and 1 could also be much less necessary than the distinction 363 between grade three and grades 2 and 1. Of observe, Li discovered no 347 association between pathologic grade and contralateral invasive cancers. Li discovered women with comedo necrosis have been at 347 barely decreased danger of contralateral invasive recurrence. Comparisons between other architectural groups are hardly ever reported and are considerably 295 inconsistent. Three observational research 301,348,358 showed a optimistic tendency between necrosis and worse charges of any recurrence however solely 301 329,337,364 one discovered a significant association. The association was not important 369 348 after mastectomy or skin-sparing mastectomy, inconsistent in direction and significance 306,311,360,369,370 after lumpectomy plus radiation, and in research that mixed all treatment 312,315,316,329,335,339,345 together in evaluation. The Van Nuys Index is scored from four-12 based mostly on four different predictors of native breast recurrence: tumor size, width of unfavorable margin, pathologic classification, and 371 patient age. The index measures publish-surgical danger of events (since surgical margins comprise one-quarter of the score). The association between patient outcomes and Van Nuys danger category was examined in 15 317,336,341,343,349,350,352,358,371-377 observational research (Table 17). Some research included 376 age, grade, and tumor size however not surgical margins, calculated tumor size from mammographic 358 lesion, or modified cut offs for nuclear grade (low=1, intermediate=2, excessive=three) and margin 374 (>1mm score=2,? Women at the highest danger category of Van Nuys index (10-12) had 224 % higher odds 350 of mortality than women within the four to 6 danger category. Few research report the association between estrogen receptor status and mortality. They concluded that coexpression of Her2 and Her4 was associated with decreased recurrence in contrast with Her2 solely tumors. The significance of Her2 positivity is highlighted by a research by Bijker which discovered a kappa of. It is much less clear whether or not the age-related disadvantage is attenuated when comparing middle aged and older women. For instance, Innos reported similar recurrence charges between women between 50 and sixty five and those 364 over sixty five. Likewise, Li discovered recurrence charges for ladies between 50-59 and 60-sixty nine or 70+ to be eighty 347 307 298,318,370 296 equivalent. In 347 contrast, Li discovered elevated danger of contralateral invasive cancer to be greater in older women. All-trigger mortality, nonetheless, is persistently lower in younger women than older eighty,389 women. Consistent with the elevated danger of recurrence in younger women, three research discovered pre 309,322,333 menopausal women to face greater danger of recurrence than publish-menopausal women. These findings level to variations in tumor traits corresponding to size, grade, and necrosis as necessary explanatory components for the noticed poorer outcomes among African American versus white women. The findings also underscore the significance of tumor traits that stay after controlling for treatment. Patient outcomes for Asians or Asian-Pacific Islanders have been compared to whites in five 322,347,364,376,389 articles. The small variety of circumstances included within the evaluation limits the interpretability of these Native American comparisons. Neither reported a statistically important end result; one reported a historical past of oral contraceptive use to be a positive prognostic factor, the opposite associated with slight elevated danger (1. The research reported a nonsignificant association between some (versus no) weekly alcohol consumption and decreased danger of recurrence. All discovered a optimistic household historical past to be associated with elevated danger, though not all effects have been statistically important. However, there 344 was no important association between adherence to the rules and native recurrence. In summary, whereas observational research advised discount in breast cancer mortality after implementation of mammographic screening within the United States, the charges of native recurrence and contralateral breast cancer stay unchanged over this same interval. The recurrence charges, nonetheless, are greater (31 %) than reported by many research. A ssociationbetweentum orsiz e and patientoutcom es Included N um berof M onth s of R elative M easure ofth e A uth or,Y ear Estim ate/Design Tum orSiz e Categories Treatm ents W om en F ollowup A ssociation(ninety five% C I) A llEvents L R orL DiSaverio, 259 O R /O bservationalstudy 120 L arge vs. A ssociationbetweentum orsiz e and patientoutcom es (continued) Included N um berof M onth s of R elative M easure ofth e A uth or,Y ear Estim ate/Design Tum orSiz e Categories Treatm ents W om en F ollowup A ssociation(ninety five% C I) 347 M,L R,orL L i,2006 37,692 H R /O bservationalstudy N A M iddle vs. A ssociationbetweentum orsiz e and patientoutcom es (continued) Included N um berof M onth s of R elative M easure ofth e A uth or,Y ear Estim ate/Design Tum orSiz e Categories Treatm ents W om en F ollowup A ssociation(ninety five% C I) L R ingberg, 121 O R /O bservationalstudy 60 L arge vs. A ssociationbetweentum orgrade and patientoutcom es (continued) Included N um berof M onth s of Tum or R elative M easure ofth e O utcom es A uth or,Y ear Estim ate/Design Treatm ents W om en F ollowup G rade A ssociation(ninety five% C I) 356 C ontralateral L R orL W arnberg,1999 195 O R /O bservational fifty eight H igh vs. Nuclear grade is chosen when each pathological grade and nuclear grade are reported. A ssociationbetweenarch itecture and patientoutcom es Treatm ents N um berof M onth s of R elative M easure ofth e O utcom es A uth or;Y ear Estim ate/Design A rch itecture Included W om en F ollowup A ssociation(ninety five% C I) 325 M etastasis L R Solin,1993 172 O R /O bservational ninety six C omedo vs. A ssociationbetweennecrosis and patientoutcom es Included N um berof M onth s of Presence of R elative M easure ofth e A uth or,Y ear Estim ate/Design Treatm ents W om en F ollowup N ecrosis A ssociation(ninety five% C I) A llC ause M ortality 325 L R Solin,1993 eighty one O R /O bservationalstudy 84 Y es vs.
Eftsoones her goodly shield addressing faire generic lozol 1.5 mg online hypertension and exercise, That mortall speare she in her hand did take purchase lozol 1.5 mg without prescription blood pressure measurement, And vnto battell did her selfe prepaire buy lozol cheap blood pressure chart range. Ythrild with deepe disdaine of his proud risk discount lozol 2.5mg with visa blood pressure map, She shortly thus; Fly they, that must fly; Words fearen babes. Strongly the straunge knight ran, and sturdily Strooke her full on the brest, that made her downe Decline her head, & contact her crouper along with her crowne. But she againe him within the shield did smite, With so fierce furie and great puissaunce, That through his threesquare scuchin percing fairly, And through his mayled hauberque, by mischaunce the wicked steele through his left facet did glaunce; Him so transfixed she before her bore Beyond his croupe, the length of all her launce, Till sadly soucing on the sandie shore, He tombled on an heape, and wallowd in his gore. Whiles thus he lay in lethal stonishment, Tydings hereof came to his moms eare; His mother was the blacke-browd Cymoent, the daughter of great Nereus, which did beare this warlike sonne vnto an earthly peare, the well-known Dumarin; who on a day Finding the Nymph a sleepe in secret wheare, As he by chaunce did wander that very same means, Was taken along with her loue, and by her carefully lay. There he this knight of her begot, whom borne She of his father Marinell did identify, And in a rocky caue as wight forlorne, Long time she fostred vp, until he turned A mightie man at armes, and mickle fame Did get through great aduentures by him donne: For neuer man he suffred by that very same Rich strond to trauell, whereas he did wonne, But that he must do battell with the Sea-nymphes sonne. The God did graunt his daughters deare demaund, To doen his Nephew in all riches flow; Eftsoones his heaped waues he did commaund, Out of their hollow bosome forth to throw darkwing. All the massive threasure, which the sea below Had in his greedie gulfe deuoured deepe, And him enriched through the ouerthrow And wreckes of many wretches, which did weepe, And often waile their wealth, which he from them did keepe. Thereto he was a doughtie dreaded knight, Tryde often to the scath of many deare, That none in equall armes him matchen may, the which his mother seeing, gan to feare Least his too haughtie hardines may reare Some onerous mishap, in hazard of his life: For thy she oft him counseld to forbeare the bloudie battell, and to stirre vp strife, But in spite of everything his warre, to relaxation his wearie knife. Who through foresight of his eternall ability, Bad her from womankind to keepe him properly: For of a girl he ought to haue much unwell, A virgin strange and stout him ought to dismay, or kill. For thy she gaue him warning euery day, the loue of women to not entertaine; A lesson too too onerous for liuing clay, From loue in course of nature to refraine: Yet he his moms lore did properly retaine, And euer from faire Ladies loue did fly; Yet many Ladies faire did oft complaine, darkwing. That they for loue of him would algates dy: Dy, who so list for him, he was loues enimy. That when he sleepes in most security, And safest seemes, him soonest doth amate, And findeth dew effect or soone or late. This was that lady, this that lethal wound, That Proteus prophecide ought to him dismay, the which his mother vainely did expound, To be hart-wounding loue, which ought to assay To bring her sonne vnto his final decay. Too true the well-known Marinell it fownd, Who through late triall, on that wealthy Strond Inglorious now lies in senselesse swownd, Through heauy stroke of Britomartis hond. Which when his mother deare did vnderstond, And heauy tydings heard, whereas she playd Amongst her watry sisters by a pond, Gathering sweet daffadillyes, to haue made Gay girlonds, from the Sun their forheads faire to shade. Eftsoones both flowres and girlonds farre away She flong, and her faire deawy lockes yrent, To sorrow huge she turnd her former play, And gamesom merth to grieuous dreriment: She threw her selfe downe on the Continent, Ne phrase did speake, however lay as in a swowne, Whiles all her sisters did for her lament, With yelling outcries, and with shrieking sowne; And euery one did teare her girlond from her crowne. Soone as she vp out of her lethal fit Arose, she bad her charet to be brought, And all her sisters, that along with her did sit, Bad eke attonce their charets to be sought; Tho stuffed with bitter griefe and pensiue thought, She to her wagon clombe; clombe all the rest, And forth collectively went, with sorrow fraught. The waues obedient to their beheast, Them yielded readie passage, and their rage surceast. Great Neptune stood amazed at their sight, Whiles on his broad round backe they softly slid And eke himselfe mournd at their mournfull plight, Yet wist not what their wailing ment, yet did For great compassion of their sorrow, bid His mightie waters to them buxome bee; Eftsoones the roaring billowes still abid, And all the griesly Monsters of the See Stood gaping at their gate, and wondred them to see. A teme of Dolphins raunged in aray, Drew the smooth charet of unhappy Cymoent; They had been all taught by Triton, to obay To the long raynes, at her commaundement: As swift as swallowes, on the waues they went, That their broad flaggie finnes no fome did reare, Ne bubbling roundell they behind them sent; the rest of other fishes drawen weare, Which with their finny oars the swelling sea did sheare. Now lyest thou of life and honor reft; Now lyest thou a lumpe of earth forlorne, Ne of thy late life reminiscence is left, Ne can thy irreuocable future be weft? Fond Proteus, father of false prophecis, And they more fond, that credit score to thee giue, Not this the worke of womans hand ywis, That so deepe wound through these deare members driue. I feared loue: however they that loue do liue, But they that die, doe neither loue nor hate. Farre higher I it deeme to die with velocity, Then waste in woe and wailefull miserie. Who dyes the vtmost dolour doth abye, But who that liues, is left to waile his losse: So life is losse, and death felicitie. Sad life worse then glad death: and greater crosse To see pals graue, the[m] lifeless the graue selfe to engrosse. But if the heauens did his dayes enuie, And my quick blisse maligne, yet mote they properly Thus much afford me, ere that he did die That the dim eyes of my deare Marinell I mote haue closed, and him bed farewell, darkwing. Yet maulgre them farewell, my sweetest sweet; Farewell my sweetest sonne, sith we no more shall meet. Tho when the lilly handed Liagore, (This Liagore whylome had realized ability In leaches craft, by great Appolloes lore, Sith her whylome vpon excessive Pindus hill, He loued, and eventually her wombe did fill With heauenly seed, whereof sensible P? Tho vp him taking of their tender hands, They easily vnto her charet beare: Her teme at her commaundement quiet stands, Whiles they the corse into her wagon reare, And strow with flowres the lamentable beare: Then all the rest into their coches clim, And through the brackish waues their passage sheare; Vpon great Neptunes necke they softly swim, And to her watry chamber swiftly carry him. Deepe within the bottome of the sea, her bowre Is constructed of hollow billowes heaped hye, Like to thicke cloudes, that risk a stormy showre, And vauted all within, like to the sky, In which the Gods do dwell eternally: There they him laid in easie couch properly dight; And sent in haste for Tryphon, to apply Salues to his wounds, and medicines of may: darkwing. The whiles the Nymphes sit all about him round, Lamenting his mishap and heauy plight; And oft his mother vewing his broad wound, Cursed the hand, that did so lethal smight Her dearest sonne, her dearest harts delight. Yet did false Archimage her still pursew, To bring to passe his mischieuous intent, Now that he had her singled from the crew Of courteous knights, the Prince, and Faery gent, Whom late in chace of beautie excellent She left, pursewing that very same foster sturdy; Of whose foule outrage they impatient, And stuffed with fiery zeale, him followed long, To reskew her from disgrace, and to reuenge her incorrect. Through thick and skinny, through mountaines & through plains, Those two great cha[m]pions did attonce pursew the fearefull damzell, with incessant paines: Who from them fled, as light-foot hare from vew Of hunter swift, and sent of houndes trew. At final they came vnto a double means, Where, doubtfull which to take, her to reskew, Themselues they did dispart, every to assay, Whether more happie had been, to win so goodly pray. But Timias, the Princes mild Squire, That Ladies loue vnto his Lord forlent, And with proud enuy, and indignant ire, After that wicked foster fiercely went. But fairest fortune to the Prince befell, Whose chaunce it was, that soone he did repent, To take that means, by which that Damozell Was fled afore, affraid of him, as feend of hell. At final of her farre off he gained vew: Then gan he freshly pricke his fomy steed, And euer as he nigher to her drew, So euermore he did improve his velocity, And of every turning still kept warie heed: Aloud to her he oftentimes did name, To doe away vaine doubt, and needlesse dreed: Full myld to her he spake, and oft let fall Many meeke wordes, to stay and comfort her withall. But nothing may relent her hastie flight; So deepe the lethal feare of that foule swaine Was earst impressed in her mild spright: Like as a fearefull Doue, which through the raine, Of the broad aire her means does reduce amaine, Hauing farre off espyde a Tassell gent, Which after her his nimble wings doth straine, Doubleth her haste for feare to be for-hent, And along with her pineons cleaues the liquid firmament. With no lesse haste, and eke with no lesse dreed, That fearefull Ladie fled from him, that ment To her no euill thought, nor euill deed; Yet former feare of being fowly shent, Carried her ahead along with her first intent: And although oft wanting backward, properly she vewd, Her selfe free of that foster insolent, And that it was a knight, which now her sewd, Yet she no lesse the knight feard, then that villein impolite. His vncouth shield and straunge armes her dismayd, Whose like in Faery lond had been seldome seene, That fast she from him fled, no lesse affrayd, Then of wilde beastes if she had chased beene: Yet he her followd still with courage keene, So long that now the golden Hesperus Was mounted excessive in top of heauen sheene, And warnd his other brethren ioyeous, To light their blessed lamps in Ioues eternall hous. All suddenly dim woxe the dampish ayre, And griesly shadowes couered heauen bright, That now with thousand starres was decked fayre; darkwing. Which when the Prince beheld, a lothfull sight, And that perforce, for need of lenger light, He mote surcease his go well with, and lose the hope Of his long labour, he gan fowly wyte His wicked fortune, that had turnd aslope, And cursed evening, that reft from him so goodly scope. Tho when her wayes he could no more descry, But to and fro at disauenture strayd; Like as a ship, whose Lodestarre suddenly Couered with cloudes, her Pilot hath dismayd; His wearisome pursuit perforce he stayd, And from his loftie steed dismounting low, Did let him forage. Downe himselfe he layd Vpon the grassie ground, to sleepe a throw; the cold earth was his couch, the onerous steele his pillow. But mild Sleepe enuyde him any relaxation; In stead thereof unhappy sorrow, and disdaine Of his onerous hap did vexe his noble brest, And thousand fancies wager his idle braine With their light wings, the sights of semblants vaine: Oft did he wish, that Lady faire mote bee His Faery Queene, for whom he did complaine: Or that his Faery Queene had been such, as shee: And euer hastie Night he blamed bitterlie. Night thou foule Mother of annoyance unhappy, Sister of heauie death, and nourse of woe, Which wast begot in heauen, however for thy bad And brutish form thrust downe to hell below, Where by the grim floud of Cocytus sluggish Thy dwelling is, in Herebus blacke hous, (Blacke Herebus thy husband is the foe Of all the Gods) the place thou vngratious, Halfe of thy dayes doest lead in horrour hideous. Indeed in sleepe the slouthfull bodie, that doth loue to steepe His lustlesse limbes, and drowne his baser mind, darkwing. Doth praise thee oft, and oft from Stygian deepe Calles thee, his goddesse in his error blind, And great Dame Natures handmaide, chearing euery sort. But properly I wote, that to an heauy hart Thou artwork the foundation and nurse of bitter cares, Breeder of new, renewer of previous smarts: In stead of relaxation thou lendest rayling teares, In stead of sleepe thou sendest troublous feares, And dreadfull visions, within the which aliue the drearie image of unhappy death appeares: So from the wearie spirit thou doest driue Desired relaxation, and males of happinesse depriue. Dayes dearest youngsters be the blessed seed, Which darknesse shall subdew, and heauen win; Truth is his daughter; he her first did breed, Most sacred virgin, without spot of sin. O when will day then turne to me againe, And bring with him his long anticipated light? O Titan, haste to reare thy ioyous waine: Speed thee to spred abroad thy beames bright? And push back this too long lingring evening, Chase her away, from whence she came, to hell. Thus did the Prince that wearie evening outweare, In restlesse anguish and vnquiet paine: And earely, ere the morrow did vpreare His deawy head out of the Ocean maine, He vp arose, as halfe in great disdaine, And clombe vnto his steed. Prince Arthur heares of Florimell: three fosters Timias wound, Belphebe finds him almost lifeless, and reareth out of sownd. Ne suffereth it vncomely idlenesse, In his free thought to build her sluggish nest: Ne suffereth it thought of vngentlenesse, Euer to creepe into his noble brest, But to the very best and the worthiest darkwing. Lifteth it vp, that else would lowly fall: It lets not fall, it lets it to not relaxation: It lets not scarse this Prince to breath at all, But to his first poursuit him ahead still doth name. Who very long time wandred through the forrest wyde, To finde some issue thence, until that finally He met a Dwarfe, that appeared terrifyde With some late perill, which he hardly previous, Or other accident, which him aghast; Of whom he asked, whence he recently came, And whither now he trauelled so fast: For sore he swat, and running through that very same Thicke forest, was bescratcht, & both his toes nigh lame. Panting for breath, and almost out of hart, the Dwarfe him answerd, Sir, unwell mote I stay To inform the identical. I recently did depart From Faery court docket, the place I haue many a day Serued a gentle Lady of great sway, And excessive accompt throughout all Elfin land, Who recently left the identical, and tooke this manner: Her now I seeke, and if ye vnderstand Which means she fared hath, good Sir inform out of hand. Royally clad (quoth he) in cloth of gold, As meetest might beseeme a noble mayd; Her faire lockes in wealthy circlet be enrold, A fairer wight did neuer Sunne behold, And on a Palfrey rides more white then snow, Yet she her selfe is whiter manifold: the surest signe, whereby ye might her know, Is, that she is the fairest wight aliue, I trow. Perdy me leuer had been to weeten that, (Said he) then ransome of the richest knight, Or all the great that euer yet I gat: But froward fortune, and too ahead Night Such happinesse did, maulgre, to me spight, And fro me reft both life and light attone. A Sea-nymphes sonne, that Marinell is hight, Of my deare Dame is loued dearely properly; In other none, however him, she units delight, All her delight is ready on Marinell; But he units nought at all by Florimell: For Ladies loue his mother long ygoe Did him, they are saying, forwarne through sacred spell. But fame now flies, that of a forreine foe He is yslaine, which is the ground of all our woe. Fiue dayes there be, since he (they are saying) was slaine, And foure, since Florimell the Court for-went, And vowed neuer to returne againe, Till him aliue or lifeless she did inuent. Therefore, faire Sir, for loue of knighthood gent, And honour of trew Ladies, if ye might By your good counsell, or bold hardiment, Or succour her, or me direct the way in which; Do one, or other good, I you most humbly pray. So might ye gaine to you full great renowme, Of all good Ladies through the world so broad, And haply in her hart find highest rowme, Of whom ye seeke to be most magnifide: At least eternall meede shall you abide. To whom the Prince; Dwarfe, comfort to thee take, For until thou tidings learne, what her betide, I right here auow thee neuer to forsake. Who all this while full hardly was assayd Of lethal daunger, which to him betid; For whiles his Lord pursewd that noble Mayd, After that foster fowle he fiercely rid, To bene auenged of the disgrace, he did To that faire Damzell: Him he chaced long Through the thicke woods, whereby he would haue hid His shamefull head from his auengement sturdy. Nathlesse the villen sped him selfe so properly, Whether through swiftnesse of his speedy beast, Or information of these woods, the place he did dwell, That shortly he from daunger was releast, And out of sight escaped at least; Yet not escaped from the dew reward Of his bad deeds, which dayly he increast, Ne ceased not, until him oppressed onerous the heauy plague, that for such leachours is prepard. Tho to his brethren came: for they had been three Vngratious youngsters of 1 gracelesse sire, And vnto them complained, how that he Had vsed bene of that foolehardy Squire; So them with bitter words he stird to bloudy ire. Within that wood there was a couert glade, Foreby a slim foord, to them properly knowne, Through which it was vneath for wight to wade; And now by fortune it was ouerflowne: By that very same means they knew that Squire vnknowne Mote algates passe; for thy, themselues they set There in await, with thicke woods ouer growne, And all the while their malice they did whet With cruell threats, his passage through the ford to let. It fortuned, as they deuized had, the mild Squire came ryding that very same means, Vnweeting of their wile and treason bad, And through the ford to passen did assay; But that fierce foster, which late fled away, Stoutly forth stepping on the further shore, Him boldly bad his passage there to stay, Till he had made amends, and full restore For all the harm, which he had him doen afore. He tombling downe, with gnashing teeth did bite the bitter earth, and bad to let him in Into the balefull house of endlesse evening, Where wicked ghosts do waile their former sin. That seeing now the onely final of three, Who with that wicked shaft him wounded had, Trembling with horrour, as that did foresee the fearefull finish of his auengement unhappy, Through which he comply with ought to his brethren bad, His bootelesse bow in feeble hand vpcaught, And therewith shot an arrow at the lad; Which faintly fluttring, scarce his helmet raught, And glauncing fell to ground, however him aggravated naught. He liues, however takes small ioy of his renowne; For of that cruell wound he bled so sore, That from his steed he fell in lethal swowne; Yet still the bloud forth gusht in so great store, That he lay wallowd all in his owne gore. Now God thee keepe, thou gentlest Squire aliue, Else shall thy louing Lord thee see no more, But both of comfort him thou shalt depriue, And eke thy selfe of honour, which thou didst atchiue. Prouidence heauenly passeth liuing thought, And doth for wretched mens reliefe make means; For loe great grace or fortune thither brought Comfort to him, that comfortlesse now lay. In those same woods, ye properly bear in mind might, How that a noble hunteresse did wonne, She, that base Braggadochio did affray, And made him fast out of the forrest runne; Belphoebe was her identify, as faire as Phoebus sunne. Shortly she came, whereas that woefull Squire With bloud deformed, lay in lethal swownd: In whose faire eyes, like lamps of quenched hearth, the Christall humour stood congealed rownd; His locks, like pale leaues fallen to grownd, Knotted with bloud, in bounches rudely ran, And his sweete lips, on which before that stownd the bud of youth to blossome faire started, Spoild of their rosie pink, had been woxen pale and wan.
Green fruit incorporates two substances safe lozol 1.5 mg pulse pressure 30 mmhg, known as "pectase" and "pectose" and buy lozol on line amex blood pressure medication ear ringing, by the action of the solar in ripening order lozol with a visa pulse pressure 80 mmhg, these substances become pectin which makes fruit jelly. Nearly all failures in jelly making are due both to over-ripe fruit or to the use of too much warmth, as a result of in both cases the pectin is lost. Remove the glasses and drain; place, whereas filling, on a cloth wrung out of scorching water. Melt the paraffin over scorching water and pour over the jelly when chilly about one-fourth inch thick. Bind the highest with tape and finish with two or three heavy loops by which it may be hung. With fruit corresponding to apples or quinces add enough water to cover them, but with watery fruits, corresponding to grapes and currants, omit any water. Allow all of the juice possible to drip by way of earlier than squeezing the bag and maintain this juice by itself. Measure the juice, bring to the boiling level, boil slowly two or three minutes, then add an equal amount of heated sugar. Put into granite or, porcelain lined preserving kettle and add enough chilly water to come back practically to the highest of the apples. Boil slowly for about 20 minutes, add an equal amount of heated sugar, cook dinner for about five minutes or until the jelly will harden when dropped on a chilly saucer. Strain by way of a jelly bag, return the juice to the kettle and boil slowly for about five minutes. Wash the grapes, take away the stems and squeeze the pulp from the skins into a preserving kettle. Strain by way of a sieve, add the skins to the strained mixture, measure, return to the kettle, and add an equal quantity of sugar. Remove the leaves and items of root from the rhubarb and wash the stalks in chilly water. Wash the oranges and both grate the rind or minimize the yellow into strips thin enough to be seen by way of. Cook slowly, stirring continuously, until the mixture is thick,-about three-quarters of an hour. Force by way of a fantastic sieve, return to the hearth with a scant pound of sugar and the juice and rind of one lemon for every pound of pulp. Cook, stirring with a wooden spoon until the marmalade is thick when dropped on a chilly saucer. Among one of the best are cinnamon, cloves, nutmeg, grated rind and juice of oranges and lemons. When seasoned based on taste, add sugar to the pulp, and cook dinner until of the desired consistency. The rind of the orange could also be grated and cooked by itself until tender earlier than including to the remainder of the supplies. Strain or not as desired, but when strained put again in the kettle and bring to the boiling level earlier than scaling. The chili sauce is sort of "scorching," but this may be remedied by altering the number of peppers and onions. The peppers must be washed in chilly water, the stems removed and the peppers chopped finely. Put the cucumbers and onions in a crock, pour over the mixture and add enough vinegar to cover. In the morning take away from the brine, put in a granite kettle, cover with vinegar to which has been added mustard seeds, complete cloves, stick cinnamon, two cups of sugar and other desired seasonings. Slice and sprinkle one peck of tomatoes with one cup of salt and let stand over evening. Cook for 10 minutes the next: one gallon of vinegar, 2 kilos or less of sugar, 1 red pepper, 10 teaspoon mustard seed, 3/4 cup cinnamon bark, and another seasonings desired. To the housekeeper who needs to save lots of herself and to serve her friends with food at its best, the chafing dish comes as a suitable good friend to be used on the breakfast table in the preparation of eggs and dishes which must be served instantly. Toast can be served recent and scorching through the use of a toaster over the burner of a chafing dish. At luncheon a scorching dish can simply take the place of the chilly meat course if the chafing dish is at hand. However, the chief use of the chafing dish is in the preparation of late suppers, and is basically in use by those that have limited facilities for housekeeping, corresponding to school ladies. By those that entertain the chafing dish is looked upon as a real good friend of hospitality. Chafing dishes differ in worth from the frequent ones manufactured from tin which can be bought for a few greenback, to the dearer ones manufactured from silver. Among those most passable are graniteware, earthenware, nickel, copper and aluminum. There must be a pan to make use of for hot water, and it must be furnished with a deal with. Until one becomes an skilled the hot water pan must be in constant use but later one want solely use the hot water pan for preserving food warm. Fill the lamp with sufficient alcohol to cook dinner the dish desired, and if necessary to refill during cooking shut off the flame and let the burner cool somewhat earlier than replenishing with the alcohol. A giant tray upon which to set the chafing dish prevents danger of fire and protects the table. Large forks and spoons, made especially for the chafing dish, can be obtained at a small worth, but any table spoon and fork can he used. It is properly to have a napkin and further spoon and fork at hand if it is necessary to taste the preparation. That a chafing dish supper could also be successful, care must be taken on the a part of the hostess to have every little thing in readiness. If one will observe some care and have every little thing in readiness, a chafing dish supper can be a very enjoyable source of entertainment for casual affairs. To use the next recipes with success degree measurements of all ingredients have to be made-degree teaspoon, degree cup, and so forth. Melt the butter and stir in the flour and seasonings until smooth; add the scalded milk slowly, stirring continuously. This makes a medium thick sauce, the thickness of which can be varied by growing or diminishing the amount of flour. This is the inspiration for a great number of chafing dish recipes, corresponding to creamed dishes. A richer sauce might he made by substituting cream for milk and omitting a lot of the butter. Prepare one cup of thin cream sauce and season with the celery salt and curry powder. Add the rooster and when heated by way of pour over slices of toast or into timbal cases. Pour the mixture over rounds of toast and excessive of each portion sprinkle a number of the yolk which was compelled by way of the potato ricer as a garnish. When the eggs are poached serve on the toast which has been dipped in melted butter. Follow directions for welsh rarebit (above) including the soda with the cheese and the milk rather than the ale. A shorter technique is to take away skins and dry the nuts, then cook dinner in olive oil until brown, and whereas draining to sprinkle them with salt. In this list are lots of the foreign words used on menu cards in resorts, with their translation: Cafe-Coffee. Puree-Ingredients rubbed by way of a sieve; usually the time period given a thick strained soup. When these are carried out put in a jar or kettle a layer of quinces, then of apples until all are used. Pour over them a syrup manufactured from a half pound of sugar to pound of quinces, dissolved in slightly water and let it stand over evening. Remove from the hearth and beat up totally, including a teaspoonful of butter to a quart of apple sauce, half cup sugar and grate in 1 / 4 of nutmeg. When the syrup has come to a quick boil, put in the pears rigorously and boil until they appear clear and can be simply pierced with a fork, which will probably be about twenty minute. Be positive that every one the eyes are minimize out, as the fruit will spoil rapidly if these remain in. When this syrup becomes thick enough, add the fruit and let boil about fifteen minutes. Remove this from the hearth and add an equal amount of brandy whereas the syrup continues to be scorching. Wash properly and put in glass jars, into which has been poured a cupful of chilly water. Cut the corn from the cob and put in glass jars, pack down tightly and screw covers on loosely to allow the air to escape. Set the jars in a boiler and fill the boiler with chilly water until it reaches the rim of the jars and let boil for 4 hours. A good plan is to put a board or some corn husks in the backside of the boiler on which to set the jars to forestall them from cracking. Slice both of these in separate kettles, sprinkling salt between the tomatoes, then letting them stand two hours. After the tomatoes have stood the desired size of time squeeze the liquid off from them, additionally the onions and arrange in a crock in alternate layers, sprinkling celery seed between them (white and black mustard seed). In the morning drain off the brine and season with one ounce tumeric, one tablespoon celery seed, half teaspoonful cayenne pepper, one ounce of the next spices, cinnamon, allspice, one ounce black pepper, one quarter ounce cloves, one cup brown sugar, vinegar enough to cover, then boil two hours. Boil them in a part of the vinegar and sugar until tender; then take them out, warmth the rest of the fluid and pour over them. If this pickle is stored in a cool, dry place, you will discover them in excellent situation on the finish of the winter. Then put into robust scorching brine, repeating this for 3 mornings, after which drain off and canopy with scorching vinegar. When needed to make use of, take out of brine and stuff with creamed sweetbreads and mushrooms and serve on a lettuce leaf. Place in kettle in layers and canopy with chilly vinegar, boil fifteen minutes, stirring continuously. Put in as many peaches as the liquor will cover; cook dinner until moderately soft and put into jars. Then cover with cider vinegar and boil until soft; drain once more and mix with one tablespoon cloves, identical quantity of mustard, two kilos every of raisins and sugar, one half cup grated horse-radish, three chopped onions, celery and salt to taste. A few spices in bunches and thrown in after being salted, will look red and pretty. Take a quart of cider vinegar, one cup granulated sugar, teaspoonful of salt, let this come to a boil, then pour over beets. Then take 1 quart cider vinegar, 2 ounces stick cinnamon, 1 ounce cloves, 3 kilos granulated sugar; let this boil, then add the cantelope, cooking it twenty minutes longer. Put all together on the identical time into your kettle and boil ten or fifteen minutes. Then drain properly and pull the branches in handy sized items and put into a jar of pickle, prepared as follows: Heat vinegar to boiling level, add slightly mace and complete red peppers, and pour scorching over the brocoli.
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